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Can I read Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6 on EtoBox?
Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6 by Sinead King; Laurena Holleran; David Mothersill; Saahithh Patlola; Karolina Rokita; Ross McManus; Marcus Kenyon; Colm McDonald; Brian Hallahan; Aiden Corvin; Derek Morris; John Kelly; Declan McKernan; Gary Donohoe is a Neuroscience article available to read on EtoBox.
What is Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6 about?
Objective Exposure to childhood trauma (CT) is associated with cognitive impairment in schizophrenia, and deficits in social cognition in particular. Here, we sought to test whether IL-6 mediated the association between CT and social cognition both directly, and sequentially via altered default mode network (DMN) connectivity. Methods Three-hundred-and-eleven participants (104 patients and 207 healthy participants) were included, with MRI data acquired in a subset of n = 147. CT was measured using the childhood trauma questionnaire (CTQ). IL-6 was measured in both plasma and in toll like receptor (TLR) stimulated whole blood. The CANTAB emotion recognition task (ERT) was administered to assess social cognition, and cortical connectivity was assessed based on resting DMN connectivity. Results Higher IL-6 levels, measured both in plasma and in toll-like receptor (TLR-2) stimulated blood, were significantly correlated with higher CTQ scores and lower cognitive and social cognitive function. Plasma IL-6 was further observed to partly mediate the association between higher CT scores and lower emotion recognition performance (CTQ total: βindirect −0.0234, 95% CI: −0.0573 to −0.0074; CTQ
Who reads Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Sinead King; Laurena Holleran; David Mothersill; Saahithh Patlola; Karolina Rokita; Ross McManus; Marcus Kenyon; Colm McDonald; Brian Hallahan; Aiden Corvin; Derek Morris; John Kelly; Declan McKernan; Gary Donohoe
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)