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Brain Afferents to the Medullary Dorsal Reticular Nucleus: a Retrograde and Anterograde Tracing Study in the Rat by Armando Almeida; Angeles Cobos; Isaura Tavares; Deolinda Lima is a Neuroscience article available to read on EtoBox.

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## Abstract The medullary dorsal reticular nucleus (DRt) was recently shown to belong to the supraspinal pain control system; neurons within this nucleus give origin to a descending projection that increases spinal nociceptive transmission and facilitates pain perception [Almeida __et al.__ (1999), __Eur. J. Neurosci.__, **11**, 110–122]. In the present study, the areas of the brain that may modulate the activity of DRt neurons were investigated by using of tract‐tracing techniques. Injection of a retrograde tracer into the DRt resulted in labelling in multiple areas of the brain. In the contralateral orbital, prelimbic, infralimbic, insular, motor and somatosensory cortices labelling was prominent, but a smaller ipsilateral projection from these same areas was also detected. Strong labelling was also noted in the central amygdaloid nucleus, bed nucleus of stria terminalis and substantia innominata. Labelled diencephalic areas were mainly confined to the hypothalamus, namely its lateral and posterior areas as well as the paraventricular nucleus. In the mesencephalon, the periaqueductal grey, red nucleus and deep mesencephalic nucleus were strongly labelled, whereas, in the brainste

Who reads Brain Afferents to the Medullary Dorsal Reticular Nucleus: a Retrograde and Anterograde Tracing Study in the Rat?

Author

Armando Almeida; Angeles Cobos; Isaura Tavares; Deolinda Lima

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)