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Impaired anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with diabetes mellitus: A preliminary report by Rimesh Pal; Naresh Sachdeva; Soham Mukherjee; Vikas Suri; Deepy Zohmangaihi; Sant Ram; Goverdhan Dutt Puri; Ashish Bhalla; Shiv Lal Soni; Navin Pandey; Anil Bhansali; Sanjay Kumar Bhadada is a Medicine article available to read on EtoBox.
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## Background and aims: Patients with diabetes mellitus (dm) often demonstrate impaired antibody response to influenza/hepatitis b vaccines. hence, we compared anti-sars-cov-2 antibody response in non-severe covid-19 patients with and without type 2 diabetes mellitus (t2dm). ## Methods: Records of non-severe covid-19 patients admitted at our institution between april 10, 2020 and may 20, 2020 were retrieved. qualitative detection of total (igg + igm) anti-sars-cov-2 antibody was performed using electrochemiluminescence immunoassay in plasma samples collected at least 14 days post-polymerase chain reaction (pcr) confirmation of diagnosis. ## Results: Thirty-one non-severe covid-19 patients were included. nine patients (29%) had t2dm with mean hba at admission of 8.3 ± 1.0%. anti-sars-cov-2 antibody was estimated at a median of 16 (14-17) days post-pcr confirmation of covid-19 diagnosis. only three patients (10%) were seronegative, and all had t2dm. patients with t2dm were more likely to have non-detectable anti-sars-cov-2 antibodies than those without dm (p = 0.019). ## Conclusions: Covid-19 patients with t2dm may not undergo seroconversion even after two weeks of diagnosis. impaire
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- Author
- Rimesh Pal; Naresh Sachdeva; Soham Mukherjee; Vikas Suri; Deepy Zohmangaihi; Sant Ram; Goverdhan Dutt Puri; Ashish Bhalla; Shiv Lal Soni; Navin Pandey; Anil Bhansali; Sanjay Kumar Bhadada
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)