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Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial by Peter A. Dargaville; C. Omar F. Kamlin; Francesca Orsini; Xiaofang Wang; Antonio G. De Paoli; H. Gozde Kanmaz Kutman; Merih Cetinkaya; Lilijana Kornhauser-Cerar; Matthew Derrick; Hilal Özkan; Christian V. Hulzebos; Georg M. Schmölzer; Ajit Aiyappan; Brigitte Lemyre; Sheree Kuo; Victor S. Rajadurai; Joyce O’Shea; Manoj Biniwale; Rangasamy Ramanathan; Alla Kushnir; David Bader; Mark R. Thomas; Mallinath Chakraborty; Mariam J. Buksh; Risha Bhatia; Carol L. Sullivan; Eric S. Shinwell; Amanda Dyson; David P. Barker; Amir Kugelman; Tim J. Donovan; Kevin C. W. Goss; Markus K. Tauscher; Vadivelam Murthy; Sanoj K. M. Ali; Howard W. Clark; Roger F. Soll; Samantha Johnson; Jeanie L. Y. Cheong; John B. Carlin; Peter G. Davis; Brian A Darlow; Michael Dunn; Amy Salter; Karen Butterley; Nicky Stephens; Lizzy Reid; Ross Dunn; Luke Stephens; Tammy Matzolic; Brenda Argus; Emily Twitchell; Joanna Barrotta; Elizabeth Noble; Kenneth Tan; Emma Yeomans; Melissa Lai; Pieter Koorts; Margaret Broom; Brenda Law; Po-Yin Cheung; Sylvia Van Os; Caroline Fray; Nicole Huneault-Purney; Melissa Faulkner; Chantal Horth; Rebecca Grimwood; A Riskin; Tatiana Kalinina; C Tsafrir; S Afuta; Fanny Timstut; Sabine Huth; Frances McCaffrey; Helmut Hummler; Samir Gupta; Mary Dinan; Miriam Casiraghi; Yip Wai Yan; Krishna R Gopagondanahalli; Suresh Chandran; Rowena Dela Puerta; Miha Lučovnik; Vlasta L Kurtovič; Annelies J Olthuis; Dyvonne H Baptist; Helene A Bouma; Mehmet Büyüktiryaki; Suzan Sahin; Burcu Cebeci; Sule Ozdemir; Aylin Vantansever; Lorna McKay; Therese McSorley; Philippa Crowley; Jenny Pond; Christie Mellish; Rachel M Hayward; Ian P Morris; Sian Elliot; Deena-Shefali Patel; Izabela Andrzejewska; Amanda Cook; Sue Wolf; Micah Tong; Rosanna Ericksen; Amanda Logan; Patricia Niblack; Zenaida R Tauscher; Pamela Whitlow; OPTIMIST-A Trial Investigators is a Medicine article available to read on EtoBox.
What is Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial about?
## Importance The long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified. ## Objective To examine the effect of MIST on death or neurodevelopmental disability (NDD) at 2 years’ corrected age. ## Design, Setting, and Participants Follow-up study of a randomized clinical trial with blinding of clinicians and outcome assessors conducted in 33 tertiary-level neonatal intensive care units in 11 countries. The trial included 486 infants with a gestational age of 25 to 28 weeks supported with continuous positive airway pressure (CPAP). Collection of follow-up data at 2 years’ corrected age was completed on December 9, 2022. ## Interventions Infants assigned to MIST (n = 242) received exogenous surfactant (200 mg/kg poractant alfa) via a thin catheter; those assigned to the control group (n = 244) received sham treatment. ## Main Outcomes and Measures The key secondary outcome of death or moderate to severe NDD was assessed at 2 years’ corrected age. Other secondary outcomes included components of this composite outcome, as well as hospitaliza
Who reads Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Peter A. Dargaville; C. Omar F. Kamlin; Francesca Orsini; Xiaofang Wang; Antonio G. De Paoli; H. Gozde Kanmaz Kutman; Merih Cetinkaya; Lilijana Kornhauser-Cerar; Matthew Derrick; Hilal Özkan; Christian V. Hulzebos; Georg M. Schmölzer; Ajit Aiyappan; Brigitte Lemyre; Sheree Kuo; Victor S. Rajadurai; Joyce O’Shea; Manoj Biniwale; Rangasamy Ramanathan; Alla Kushnir; David Bader; Mark R. Thomas; Mallinath Chakraborty; Mariam J. Buksh; Risha Bhatia; Carol L. Sullivan; Eric S. Shinwell; Amanda Dyson; David P. Barker; Amir Kugelman; Tim J. Donovan; Kevin C. W. Goss; Markus K. Tauscher; Vadivelam Murthy; Sanoj K. M. Ali; Howard W. Clark; Roger F. Soll; Samantha Johnson; Jeanie L. Y. Cheong; John B. Carlin; Peter G. Davis; Brian A Darlow; Michael Dunn; Amy Salter; Karen Butterley; Nicky Stephens; Lizzy Reid; Ross Dunn; Luke Stephens; Tammy Matzolic; Brenda Argus; Emily Twitchell; Joanna Barrotta; Elizabeth Noble; Kenneth Tan; Emma Yeomans; Melissa Lai; Pieter Koorts; Margaret Broom; Brenda Law; Po-Yin Cheung; Sylvia Van Os; Caroline Fray; Nicole Huneault-Purney; Melissa Faulkner; Chantal Horth; Rebecca Grimwood; A Riskin; Tatiana Kalinina; C Tsafrir; S Afuta; Fanny Timstut; Sabine Huth; Frances McCaffrey; Helmut Hummler; Samir Gupta; Mary Dinan; Miriam Casiraghi; Yip Wai Yan; Krishna R Gopagondanahalli; Suresh Chandran; Rowena Dela Puerta; Miha Lučovnik; Vlasta L Kurtovič; Annelies J Olthuis; Dyvonne H Baptist; Helene A Bouma; Mehmet Büyüktiryaki; Suzan Sahin; Burcu Cebeci; Sule Ozdemir; Aylin Vantansever; Lorna McKay; Therese McSorley; Philippa Crowley; Jenny Pond; Christie Mellish; Rachel M Hayward; Ian P Morris; Sian Elliot; Deena-Shefali Patel; Izabela Andrzejewska; Amanda Cook; Sue Wolf; Micah Tong; Rosanna Ericksen; Amanda Logan; Patricia Niblack; Zenaida R Tauscher; Pamela Whitlow; OPTIMIST-A Trial Investigators
- Publisher
- American Medical Association (AMA)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)