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Autologous chondrocyte implantation (ACI) for the treatment of large and complex cartilage lesions of the knee by Ossendorf, Christian ;Steinwachs, Matthias R ;Kreuz, Peter C ;Osterhoff, Georg ;Lahm, Andreas ;Ducommun, Pascal P ;Erggelet, Christoph is a Medicine article available to read on EtoBox.
What is Autologous chondrocyte implantation (ACI) for the treatment of large and complex cartilage lesions of the knee about?
## Background Complex cartilage lesions of the knee including large cartilage defects, kissing lesions, and osteoarthritis (OA) represent a common problem in orthopaedic surgery and a challenging task for the orthopaedic surgeon. As there is only limited data, we performed a prospective clinical study to investigate the benefit of autologous chondrocyte implantation (ACI) for this demanding patient population. ## Methods Fifty-one patients displaying at least one of the criteria were included in the present retrospective study: (1.) defect size larger than 10 cm^2^; (2.) multiple lesions; (3.) kissing lesions, cartilage lesions Outerbridge grade III-IV, and/or (4.) mild/moderate osteoarthritis (OA). For outcome measurements, the International Cartilage Society's International Knee Documentation Committee's (IKDC) questionnaire, as well as the Cincinnati, Tegner, Lysholm and Noyes scores were used. Radiographic evaluation for OA was done using the Kellgren score. ## Results and Discussion Patient's age was 36 years (13-61), defects size 7.25 (3-17.5) cm^2^, previous surgical procedures 1.94 (0-8), and follow-up 30 (12-63) months. Instruments for outcome measurement indicated signifi
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- Author
- Ossendorf, Christian ;Steinwachs, Matthias R ;Kreuz, Peter C ;Osterhoff, Georg ;Lahm, Andreas ;Ducommun, Pascal P ;Erggelet, Christoph
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central; Springer Science and Business Media LLC (ISSN 1758-2555)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)