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Induction of cell arrest in G2: structural specificity of trigonelline by David G. Lynn; David H. Lewis; William A. Tramontano; Lance S. Evans is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Synthetic analogues of N-methyl nicotinic acid, trigonelline, were prepared to test the structural features necessary for the induction of cellular arrest in G2 in P~sum satioum. Analogues that (1) were regioisomers of tngonelhne, (2) possessed different 1,3-substituents, and (3) contained additional substituents on the pyrldine ring were tested for their ability to induce cell arrest in G2 and to antagonize trigonelline induced arrest in G2. Only N-methyl-3quinoline-carboxylic acid and l-methyl nicotinamlde induced cell arrest in G2, and 1-methyl-4-pyridme carboxylic acid and l-methyl-Zpyridine carboxylic acid were effective trigonelhne antagonists. These data further support a specific role for trigonelhne in the induction of cell arrest in G2.

Who reads Induction of cell arrest in G2: structural specificity of trigonelline?

Author

David G. Lynn; David H. Lewis; William A. Tramontano; Lance S. Evans

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0031-9422)

Published

1984

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)