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Novel LSD1 Inhibitors for AML Treatment by Clarisse Fetter is a document available to read on EtoBox.
This research identifies six novel and potent LSD1 inhibitors for treating acute myeloid leukemia (AML), with LTM-1 showing the most significant inhibitory effects and antitumor activity both in vitro and in vivo. The study utilized a comprehensive multi-step integrated screening approach, including pharmacophore modeling and molecular dynamics simulation, to discover these inhibitors. The promising results suggest that LTM-1 could be a valuable preclinical candidate, addressing the urgent need for effectiv
- Author
- Clarisse Fetter
- Language
- EN