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Can I read Effect of Antimicrobial Administration on Fecal Microbiota of Critically Ill Dogs: Dynamics of Antimicrobial Resistance Over Time on EtoBox?

Effect of Antimicrobial Administration on Fecal Microbiota of Critically Ill Dogs: Dynamics of Antimicrobial Resistance Over Time by Menard, Julie (author);Goggs, Robert (author);Mitchell, Patrick (author);Yang, Yufan (author);Robbins, Sarah (author);Franklin-Guild, Rebecca J. (author);Thachil, Anil J. (author);Altier, Craig (author);Anderson, Renee (author);Putzel, Gregory G. (author);McQueary, Holly (author);Goodman, Laura B. (author) is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Effect of Antimicrobial Administration on Fecal Microbiota of Critically Ill Dogs: Dynamics of Antimicrobial Resistance Over Time about?

## Background Multidrug resistance in companion animals poses significant risks to animal and human health. Prolonged antimicrobial drug (AMD) treatment in animals is a potential source of selection pressure for antimicrobial resistance (AMR) including in the gastrointestinal microbiota. We performed a prospective study of dogs treated for septic peritonitis, pyometra, or bacterial pneumonia and collected repeated fecal samples over 60 days. Bacterial cultures and direct molecular analyses of fecal samples were performed including targeted resistance gene profiling. ## Results Resistant __Escherichia coli__ increased after 1 week of treatment (D1:21.4% vs. D7:67.9% __P__ < 0.001) and returned to baseline proportions by D60 (D7:67.9% vs D60:42.9%, __P__ = 0.04). Dogs with septic peritonitis were hospitalized significantly longer than those with pneumonia or pyometra. Based on genetic analysis, Simpson’s diversity index significantly decreased after 1 week of treatment (D1 to D7, __P__ = 0.008), followed by a gradual increase to day 60 (D1 and D60, __P__ = 0.4). Detection of CTX-M was associated with phenotypic resistance to third-generation cephalosporins in __E. coli__ (OR 12.1, 3.

Who reads Effect of Antimicrobial Administration on Fecal Microbiota of Critically Ill Dogs: Dynamics of Antimicrobial Resistance Over Time?

It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.

Author
Menard, Julie (author);Goggs, Robert (author);Mitchell, Patrick (author);Yang, Yufan (author);Robbins, Sarah (author);Franklin-Guild, Rebecca J. (author);Thachil, Anil J. (author);Altier, Craig (author);Anderson, Renee (author);Putzel, Gregory G. (author);McQueary, Holly (author);Goodman, Laura B. (author)
Publisher
Springer Science and Business Media LLC
Published
2022
Language
EN
Field
Agricultural and Biological Sciences (Life Sciences)

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