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Resveratrol Induces Vasorelaxation of Mesenteric and Uterine Arteries from Female Guinea-pigs by Ebrahim K. NADERALI; Patrick J. DOYLE; Gareth WILLIAMS is a scholarly article available to read on EtoBox.

What is Resveratrol Induces Vasorelaxation of Mesenteric and Uterine Arteries from Female Guinea-pigs about?

Naturally occurring hydroxystilbenes have been shown to induce vasorelaxation. Here, we studied the mechanism of resveratrol-induced vasorelaxation in different types of blood vessels, namely mesenteric (resistance) and main uterine (conductance) arteries, from female guinea-pigs on day 7 and day 15 of the oestrous cycle. Resveratrol (5–70 μmol/l) induced concentration-dependent relaxation of both mesenteric and uterine arteries preconstricted with either noradrenaline (NA; 10 μmol/l) or KCl (125 mmol/l). Resveratrol was 2-fold more potent in inducing relaxation of mesenteric arteries than of uterine arteries. Its effects on uterine arteries from both day-7 and day-15 guinea-pigs were similar, irrespective of the constrictor used, but it was significantly (P < 0.01) more potent in inducing relaxation of mesenteric arteries contracted with NA compared with those constricted with KCl. In day-7 arteries precontracted with NA, NG-nitro-l-arginine methyl ester (l-NAME; 10 μmol/l) had no effects on the time course of resveratrol-induced vasorelaxation in either mesenteric or uterine arteries. However, indomethacin (50 μmol/l) significantly (P < 0.05) potentiated resveratrol's effect on m

Author

Ebrahim K. NADERALI; Patrick J. DOYLE; Gareth WILLIAMS

Publisher

Portland Press Ltd.

Published

2000

Language

EN