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The research article presents the development of a mitochondria-targeting probe (mTAP) designed to selectively react with abasic sites in mitochondrial DNA (mtDNA) to prevent its loss under genotoxic stress. mTAP effectively forms stable oxime conjugates with mitochondrial AP sites, reducing DNA cleavage by endonuclease APE1 and preserving mtDNA levels and transcription without compromising replication. This innovative approach highlights mTAP

Author

erika

Language

EN