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Serotype-specific Mucosal Immune Response and Subsequent Poliovirus Replication in Vaccinated Children by Elena Samoilovich; Merja Roivainen; L.P. Titov; Tapani Hovi is a Medicine article available to read on EtoBox.

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## Abstract A total of 32 unimmunized children (median age 5 months) living in an orphanage in Minsk, Belarus, were vaccinated with three doses of oral poliovirus vaccine (OPV) with a 60‐day interval between the doses. Blood samples were drawn before the immunizations and 45–50 days after each vaccine dose. Excretion of the vaccine viruses was followed by examining fecal specimens collected weekly after each vaccine dose. All children seroconverted by the second dose of OPV at the latest to all three serotypes of poliovirus but differences were seen regarding the intestinal responses. The strongest responses in both neutralizing antibodies and virus‐binding IgA in fecal suspensions were seen toward poliovirus Type 2. Consistent with this, relatively little poliovirus Type 2 excretion was seen after the second and third doses of OPV as compared to that of poliovirus Type 1 or Type 3. The delayed development of functional intestinal immunity against the latter serotypes was associated with relatively weaker intestinal antibody responses compared to poliovirus Type 2. In the case of poliovirus Type 3, about 10% of children were still excreting the vaccine virus 9 weeks after administe

Who reads Serotype-specific Mucosal Immune Response and Subsequent Poliovirus Replication in Vaccinated Children?

Author

Elena Samoilovich; Merja Roivainen; L.P. Titov; Tapani Hovi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2003

Language

EN

Field

Medicine (Health Sciences)