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Tissue Uptake Study and Photodynamic Therapy of Melanoma‐Bearing Mice with a Nontoxic, Effective Chlorin by Dr. Janusz M. Dąbrowski; Martyna Krzykawska; Prof. Luis G. Arnaut; Prof. Mariette M. Pereira; Carlos J. P. Monteiro; Prof. Sérgio Simões; Prof. Krystyna Urbańska; Prof. Grażyna Stochel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tissue Uptake Study and Photodynamic Therapy of Melanoma‐Bearing Mice with a Nontoxic, Effective Chlorin about?
## Abstract Chlorins have intense red absorptions and high tumor affinities that make them interesting candidates for photodynamic therapy (PDT) of cancer. This paper reports cytotoxicity, phototoxicity, in vitro cellular uptake, and in vivo biodistribution and PDT efficacy of a synthetic chlorin derivative (TCPCSO~3~H) towards Cloudman melanoma cells (S91). No cytotoxic effects were observed in vitro at concentrations up to 20 μm, and no toxicity was observed in vivo in DBA mice with doses up to 2 mg kg^−1^. Pharmacokinetics and biodistribution of TCPCSO~3~H were evaluated in vivo in DBA mice bearing S91 tumors. TCPCSO~3~H demonstrated preferential accumulation in S91 mouse melanoma, with tumor‐to‐normal tissue ratios of 5 and 11 for muscle and skin, respectively, 24 h after intravenous injection of 2 mg kg^−1^. Photodynamic therapy performed under these conditions with 70 mW cm^−2^ diode laser irradiation at 655 nm for 25 min (total light dose=105 J cm^−2^) resulted in scab formation, followed by temporary or permanent (>60 days) tumor remission. According to the Kaplan–Meier analysis, the median survival time of the control group was 9 days, whereas that of the treated group was
Who reads Tissue Uptake Study and Photodynamic Therapy of Melanoma‐Bearing Mice with a Nontoxic, Effective Chlorin?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dr. Janusz M. Dąbrowski; Martyna Krzykawska; Prof. Luis G. Arnaut; Prof. Mariette M. Pereira; Carlos J. P. Monteiro; Prof. Sérgio Simões; Prof. Krystyna Urbańska; Prof. Grażyna Stochel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 1860-7179)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)