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What is Stability-Function Tradeoffs in Antibiotic Resistance about?
The study investigates the stability-function tradeoffs in antibiotic resistance, specifically focusing on extended-spectrum mutants of class C β-lactamases. These mutants exhibited significant increases in activity against cefotaxime, but at the cost of thermodynamic stability, supporting the stability-function hypothesis. Structural analyses revealed distinct mechanisms of action and how substitutions distant from the active site can influence catalytic activity, highlighting constraints on the evolution
- Author
- Rubén Agudo Torres
- Language
- EN