Opening book details…
Can I read Chitinases as a Potential Diagnostic and Prognostic Biomarker for Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-analysis on EtoBox?
Chitinases as a Potential Diagnostic and Prognostic Biomarker for Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-analysis by Aoling Xu; Yujun Luo; Yudi Tang; Fen Yang; Xiaolian Gao; Guiyuan Qiao; Xinhong Zhu; Jing Zhou is a Medicine article available to read on EtoBox.
What is Chitinases as a Potential Diagnostic and Prognostic Biomarker for Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-analysis about?
## Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, and there is currently a lack of reliable diagnostic biomarkers. This meta-analysis aimed to evaluate CHIT1, CHI3L1, and CHI3L2 levels in the cerebrospinal fluid (CSF) or blood and their diagnostic potential in ALS patients. A systematic, comprehensive search was performed of peer-reviewed English-language articles published before April 1, 2023, in PubMed, Scopus, Embase, Cochrane Library, and Web of Science. After a thorough screening, 13 primary articles were included, and their chitinases-related data were extracted for systematic review and meta-analysis. In ALS patients, the CSF CHIT1 levels were significantly elevated compared to controls with healthy control (HC) (SMD, 1.92; 95% CI, 0.78 – 3.06; __P__ < 0.001). CHIT1 levels were elevated in the CSF of ALS patients compared to other neurodegenerative diseases (ONDS) control (SMD, 0.74; 95% CI, 0.22 – 1.27; __P__ < 0.001) and exhibited an even more substantial increase when compared to ALS-mimicking diseases (AMDS) (SMD, 1.15; 95% CI, 0.35 – 1.94, __P__ < 0.001). Similarly, the CSF CHI3L1 le
Who reads Chitinases as a Potential Diagnostic and Prognostic Biomarker for Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Aoling Xu; Yujun Luo; Yudi Tang; Fen Yang; Xiaolian Gao; Guiyuan Qiao; Xinhong Zhu; Jing Zhou
- Publisher
- Springer Science and Business Media LLC
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)