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Can I read Cortisol Induces Reactive Oxygen Species Through a Membrane Glucocorticoid Receptor in Rainbow Trout Myotubes: CORTISOL-MEDIATEDNON-GENOMICSIGNALINGINFISH on EtoBox?
Cortisol Induces Reactive Oxygen Species Through a Membrane Glucocorticoid Receptor in Rainbow Trout Myotubes: CORTISOL-MEDIATEDNON-GENOMICSIGNALINGINFISH by Marlen B. Espinoza; Jorge E. Aedo; Rodrigo Zuloaga; Cristian Valenzuela; Alfredo Molina; Juan A. Valdés is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cortisol Induces Reactive Oxygen Species Through a Membrane Glucocorticoid Receptor in Rainbow Trout Myotubes: CORTISOL-MEDIATEDNON-GENOMICSIGNALINGINFISH about?
Cortisol is an essential regulator of neuroendocrine stress responses in teleosts. Cortisol predominantly affects target tissues through the genomic pathway, which involves interacting with cytoplasmic glucocorticoid receptors, and thereby, modulating stress-response gene expressions. Cortisol also produces rapid effects via non-genomic pathways, which do not involve gene transcription. Although cortisol-mediated genomic pathways are well documented in teleosts, non-genomic pathways are not fully understood. Moreover, no studies have focused on the contribution of non-genomic cortisol pathways in compensatory stress responses in fish. In this study, rainbow trout (Oncorhynchus mykiss) skeletal myotubes were stimulated with physiological concentrations of cortisol and cortisol-BSA, a membrane-impermeable agent, resulting in an early induction of reactive oxygen species (ROS). This production was not suppressed by transcription or translation inhibitors, suggesting non-genomic pathway involvement. Moreover, myotube preincubation with RU486 and NAC completely suppressed cortisol- and cortisol-BSA-induced ROS production. Subcellular fractionation analysis revealed the presence of cell
Who reads Cortisol Induces Reactive Oxygen Species Through a Membrane Glucocorticoid Receptor in Rainbow Trout Myotubes: CORTISOL-MEDIATEDNON-GENOMICSIGNALINGINFISH?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Marlen B. Espinoza; Jorge E. Aedo; Rodrigo Zuloaga; Cristian Valenzuela; Alfredo Molina; Juan A. Valdés
- Published
- 2016
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)