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Gene–environment Interactions Increase the Risk of Paediatric-onset Multiple Sclerosis Associated with Household Chemical Exposures by Zahra Nasr; Vinicius Andreoli Schoeps; Amin Ziaei; Akash Virupakshaiah; Cameron Adams; T Charles Casper; Michael Waltz; John Rose; Moses Rodriguez; Jan-Mendelt Tillema; Tanuja Chitnis; Jennifer S Graves; Leslie Benson; Mary Rensel; Lauren Krupp; Amy T Waldman; Bianca Weinstock-Guttman; Tim Lotze; Benjamin Greenberg; Gregory Aaen; Soe Mar; Teri Schreiner; Janace Hart; Steve Simpson-Yap; Clementina Mesaros; Lisa F Barcellos; Emmanuelle Waubant is a Medicine article available to read on EtoBox.

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Background We previously reported an association between household chemical exposures and an increased risk of paediatric-onset multiple sclerosis. Methods Using a case–control paediatric multiple sclerosis study, gene–environment interaction between exposure to household chemicals and genotypes for risk of paediatric-onset multiple sclerosis was estimated. Genetic risk factors of interest included the two major HLA multiple sclerosis risk factors, the presence ofDRB1\*15and the absence ofA\*02,and multiple sclerosis risk variants within the metabolic pathways of common household toxic chemicals, includingIL-6(rs2069852),BCL-2(rs2187163) andNFKB1(rs7665090). Results 490 paediatric-onset multiple sclerosis cases and 716 controls were included in the analyses. Exposures to insect repellent for ticks or mosquitos (OR 1.47, 95% CI 1.06 to 2.04, p=0.019), weed control products (OR 2.15, 95% CI 1.51 to 3.07, p<0.001) and plant/tree insect or disease control products (OR 3.25, 95% CI 1.92 to 5.49, p<0.001) were associated with increased odds of paediatric-onset multiple sclerosis. There was significant additive interaction between exposure to weed control products andNFKB1SNP GG (attribut

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Author

Zahra Nasr; Vinicius Andreoli Schoeps; Amin Ziaei; Akash Virupakshaiah; Cameron Adams; T Charles Casper; Michael Waltz; John Rose; Moses Rodriguez; Jan-Mendelt Tillema; Tanuja Chitnis; Jennifer S Graves; Leslie Benson; Mary Rensel; Lauren Krupp; Amy T Waldman; Bianca Weinstock-Guttman; Tim Lotze; Benjamin Greenberg; Gregory Aaen; Soe Mar; Teri Schreiner; Janace Hart; Steve Simpson-Yap; Clementina Mesaros; Lisa F Barcellos; Emmanuelle Waubant

Publisher

BMJ

Published

2023

Language

EN

Field

Medicine (Health Sciences)