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Epidemiology, Clinical Features and Outcome of Adults with Meningococcal Meningitis: a 15-Year Prospective Nationwide Cohort Study by Thijs M. van Soest; Nora Chekrouni; Nina M. van Sorge; Merijn W. Bijlsma; Matthijs C. Brouwer; Diederik van de Beek is a Medicine article available to read on EtoBox.
What is Epidemiology, Clinical Features and Outcome of Adults with Meningococcal Meningitis: a 15-Year Prospective Nationwide Cohort Study about?
## Summary ## Background We describe the epidemiology, clinical features and outcome of adult meningococcal meningitis in the Netherlands over a 15-year period. ## Methods We studied adults (age ≥ 16 years) who were listed by the Netherlands Reference Laboratory for Bacterial Meningitis and/or included in the prospective nationwide cohort study (MeninGene) between January 2006 and July 2021. Incidences were calculated per epidemiological year (July–June). ## Findings We identified 442 episodes of adult meningococcal meningitis. The median patient age was 32 years (IQR 18–55) and 226 episodes (51%) occurred in female patients. The annual incidence per 100,000 adults fluctuated, from 0.33 in 2006–2007 to 0.05 in 2020–2021, with a temporal increase up to 0.30 from 2016 to 2018, driven by an outbreak of serogroup W (MenW). Of 442 episodes, 274 episodes (62%) in 273 patients were included in the clinical cohort study. The overall case fatality rate was 4% (10 of 274) and 16% (43 of 274) had an unfavourable outcome (Glasgow Outcome Scale score 1–4). Compared to other serogroups, MenW was associated with higher rates of unfavourable outcome (6 of 16 [38%] __vs.__ 37 of 251 [15%], P = 0.03
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- Author
- Thijs M. van Soest; Nora Chekrouni; Nina M. van Sorge; Merijn W. Bijlsma; Matthijs C. Brouwer; Diederik van de Beek
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)