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Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry by H. F. Du; L. H. Xu; H. F. Wang; Y. F. Liu; X. Y. Tang; K. X. Liu; S. X. Peng is a Environmental Science article available to read on EtoBox.

What is Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry about?

Methyl tert-butyl ether (MTBE) is a gasoline oxygenate and antiknock additive substituting for lead alkyls currently in use worldwide. Previous studies have shown that MTBE at very high doses induces tumors in rodents. The aim of the present study was to examine directly the binding ability of MTBE onto DNA, demonstrating its potential genotoxicity. MTBE-DNA adducts and their decay kinetics in mice have been measured by using doubly 14C-labeled MTBE with an advanced, ultrasensitive technique: accelerator mass spectrometry (AMS). It was found that MTBE definitely formed adducts with DNA in mouse lung, liver, and kidney in a log/log linear dose-response relationship. The distribution sequence of DNA adducts in these tissues is: lung > liver > kidney. The level of MTBE-DNA adducts peaked at 12 h postadministration in the lung and peaked at 6 h postadministration in the liver. Then the adducts declined rapidly until 5 days postadministration and thereafter declined much more slowly. To our knowledge, this is the first report on DNA adduction with MTBE in vivo. The mechanism of the formation of MTBE-DNA adducts also is discussed.

Who reads Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry?

Author

H. F. Du; L. H. Xu; H. F. Wang; Y. F. Liu; X. Y. Tang; K. X. Liu; S. X. Peng

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)

Published

2005

Language

EN

Field

Environmental Science (Physical Sciences)