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Can I read Oral Mucositis After Tacrolimus/sirolimus or Cyclosporine/methotrexate as Graft‐versus‐host Disease Prophylaxis on EtoBox?
Oral Mucositis After Tacrolimus/sirolimus or Cyclosporine/methotrexate as Graft‐versus‐host Disease Prophylaxis by Karin Garming Legert; Olle Ringdén; Mats Remberger; Johan Törlén; Jonas Mattsson; Göran Dahllöf is a Dentistry article available to read on EtoBox.
What is Oral Mucositis After Tacrolimus/sirolimus or Cyclosporine/methotrexate as Graft‐versus‐host Disease Prophylaxis about?
## Abstract ## Objectives To determine whether treatment with tacrolimus plus sirolimus (Tac/Sir) as a prophylaxis for graft‐versus‐host disease worsens severe oral mucositis and delays healing compared to cyclosporine plus methotrexate (CsA/Mtx) following haematopoietic stem cell transplantation. ## Subjects and Methods The study comprised 141 patients: 73 randomized to receive Tac/Sir and 68 to receive CsA/Mtx. The oral mucositis assessment scale and toxicity grading according to WHO were used to assess the severity, peak and duration of oral mucositis from the day −3 to day 24 post‐transplant. ## Results Eighty‐seven patients developed oral mucositis in the first 24 days post‐transplant. No significant difference in oral mucositis severity between the Tac/Sir and CsA/Mtx groups was observed. The peak oral mucositis score occurred on day 10 in both groups. Although oral mucositis scores had returned to baseline in the CsA/Mtx group on day 24 post‐transplant, no significant difference compared with the Tac/Sir group was found. ## Conclusions The introduction of tacrolimus/sirolimus as a graft‐versus‐host disease prophylaxis in haematopoietic stem cell transplantation increased nei
Who reads Oral Mucositis After Tacrolimus/sirolimus or Cyclosporine/methotrexate as Graft‐versus‐host Disease Prophylaxis?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- Karin Garming Legert; Olle Ringdén; Mats Remberger; Johan Törlén; Jonas Mattsson; Göran Dahllöf
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 1354-523X)
- Published
- 2020
- Language
- EN
- Field
- Dentistry (Health Sciences)