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Effects Of Various Serotonergic Agonists And An Antagonist On A Nociceptive Reaction In Mice by Krishnaswami RAMABADRAN; Joseph J.C. JACOB is a Medicine article available to read on EtoBox.

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Low doses of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), quipazine and cyproheptadine produced facilitation of jumping in mice using the hot plate method. Higher doses produced severe motor disturbances which precluded the assessment of effects on nociception. The observed hyperalgesia might be a consequence of diminution of serotoninergic tone resulting either from triggering of presynaptic serotoninergic receptors in the case of \(5-\mathrm{MeODMT}\) and quipazine or from the blockade of postsynaptic serotoninergic receptors in the case of cyproheptadine. The 5 -MeODMT-induced hyperalgesia was not attenuated by buprenorphine, which under similar conditions antagonized completely the hyperalgesic effects of naloxone; thus, the hyperalgesic effects of \(5-\mathrm{Me}-\) ODMT do not seemingly involve opioidergic receptors.

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Author

Krishnaswami RAMABADRAN; Joseph J.C. JACOB

Publisher

Japanese Pharmacological Society; The Japanese Pharmacological Society; Kyoto: Japan pharmacology Society; Elsevier BV (ISSN 0021-5198)

Published

1982

Language

EN

Field

Medicine (Life Sciences)