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A Multifunctional Shape-adaptive and Biodegradable Hydrogel with Hemorrhage Control and Broad-spectrum Antimicrobial Activity for Wound Healing by Lingling Gao; Jingjie Chen; Wei Feng; Qing Song; Jingjing Huo; Luofeng Yu; Nian Liu; Tengjiao Wang; Peng Li; Wei Huang is a Engineering article available to read on EtoBox.
What is A Multifunctional Shape-adaptive and Biodegradable Hydrogel with Hemorrhage Control and Broad-spectrum Antimicrobial Activity for Wound Healing about?
Hemorrhage is the leading cause of preventable death of injured military and civilian patients, and subsequent infection risks endanger their lives or impede the healing of their wounds. Here, we report an injectable biodegradable hydrogel with hemostatic, antimicrobial, and healing-promoting properties. The hydrogel was prepared by dynamic cross-linking of a natural polysaccharide (dextran) with antimicrobial peptide ε-poly-l-lysine (EPL) and encapsulating base fibroblast growth factor (bFGF). The amino groups of EPL were allowed to react with the aldehyde of oxidized dextran (OD) through the Schiff-base reaction for the generation of hydrogels that have fast self-healing and injectable characteristics and adapt to the shapes of wounds. The prepared OD/EPL hydrogels promoted blood clotting in vitro and stopped bleeding in a rat liver injury model within 6 min through their platelet-aggregating ability and sealing effect. These hydrogels exhibited inherent antimicrobial effects without the use of antibiotics and effectively killed a broad spectrum of pathogenic microbes, including Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), Gram-negative Escherichia coli, and
Who reads A Multifunctional Shape-adaptive and Biodegradable Hydrogel with Hemorrhage Control and Broad-spectrum Antimicrobial Activity for Wound Healing?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Lingling Gao; Jingjie Chen; Wei Feng; Qing Song; Jingjing Huo; Luofeng Yu; Nian Liu; Tengjiao Wang; Peng Li; Wei Huang
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)