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β-Adrenergic activity preserves GLUT4 protein in glycolytic fibers in fasting by Ana Barbara Teixeira Alves-Wagner; Helayne Soares De Freitas; Paula Bargi De Souza; Patricia Monteiro Seraphim; Rosana Cristina Tieko Mori; Ubiratan Fabres Machado is a Medicine article available to read on EtoBox.

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## Abstract Glucose transporter 4 (GLUT4) expression in adipose tissue decreases during fasting. In skeletal muscle, we hypothesized that GLUT4 expression might be maintained in a β‐adrenergic–dependent way to ensure energy disposal for contractile function. Herein we investigate β‐blockade or β‐stimulation effects on GLUT4 expression in oxidative (soleus) and glycolytic [extensor digitorum longus (EDL)] muscles of fasted rats. Fasting increased GLUT4 mRNA in soleus (24%) and EDL (40%), but the protein content increased only in soleus (30%). β1–β2‐, and β1–β2–β3‐blockade decreased (20–30%) GLUT4 mRNA content in both muscles, although GLUT4 protein decreased only in EDL. When mRNA and GLUT4 protein regulations were discrepant, changes in the mRNA poly(A) tail length were detected, indicating a posttranscriptional modulation of gene expression. These results show that β‐adrenergic activity regulates GLUT4 gene expression in skeletal muscle during fasting, highlighting its participation in preservation of GLUT4 protein in glycolytic muscle. Muscle Nerve, 2009

Who reads β-Adrenergic activity preserves GLUT4 protein in glycolytic fibers in fasting?

Author

Ana Barbara Teixeira Alves-Wagner; Helayne Soares De Freitas; Paula Bargi De Souza; Patricia Monteiro Seraphim; Rosana Cristina Tieko Mori; Ubiratan Fabres Machado

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)

Published

2009

Language

EN

Field

Medicine (Health Sciences)