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Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication by Ruizhi Zhu; Menghua Wang; Yi Xia; Fanqi Qu; Johan Neyts; Ling Peng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Novel acyclic triazole nucleosides with various ethynyl moieties appended on the triazole nucleobase were synthesized efficiently using a convenient one-step Sonogashira reaction in aqueous solution and under microwave irradiation. One of the compounds, 1f, inhibited HCV subgenomic replication with a 50% effective concentration (EC 50 ) of 22 lg/ml and did not inhibit proliferation of the host cell at a concentration of 50 lg/ml. A preliminary SAR study suggests that the appended phenyl ring as well as the rigid triple bond linker contributes importantly to the anti-HCV activity.

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Author

Ruizhi Zhu; Menghua Wang; Yi Xia; Fanqi Qu; Johan Neyts; Ling Peng

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)