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Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia by Gyeong Hoon Kang; Sun Lee; Hyeon Joo Lee; Kyu Sang Hwang is a scholarly article available to read on EtoBox.

What is Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia about?

## Abstract To date, several reports have been published about CpG island methylation of various genes in prostate cancer. However, most of these studies have focused on cancer tissue only or a single gene and data about concurrent methylation of multiple genes in prostate cancer or prostatic intraepithelial neoplasia (PIN) are limited. The aim of the present study was to determine the methylation profile of 11 tumour‐related genes in prostate cancer and PIN. Seventy‐one samples, including 37 prostate cancers, 14 PINs, and 20 normal prostates, were examined for the methylation status of 11 tumour‐related genes using methylation‐specific PCR. The mean number of genes methylated was significantly higher in prostate cancer and PIN than in non‐neoplastic prostate (4.4, 3, and 0.2, respectively; __p__ < 0.001). In prostate cancer, __APC, GSTP1, MGMT__, and __RASSF1A__ were frequently methylated at a frequency of 56.8%, 86.5%, 75.7%, and 83.8%, respectively. These genes were methylated in more than 30% of PINs. Prostate cancers with high serum prostate‐specific antigen (PSA) (more than 8 ng/ml) or a high Gleason score (GS) (3 + 4 or more) showed higher numbers of methylated genes than th

Author

Gyeong Hoon Kang; Sun Lee; Hyeon Joo Lee; Kyu Sang Hwang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2004

Language

EN