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Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters by Bala V. Manyam; Muralikrishnan Dhanasekaran; Theodore A. Hare is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract HP‐200, which contains __Mucuna pruriens__ endocarp, has been shown to be effective in the treatment of Parkinson's disease. __Mucuna pruriens__ endocarp has also been shown to be more effective compared to synthetic levodopa in an animal model of Parkinson's disease. The present study was designed to elucidate the long‐term effect of __Mucuna pruriens__ endocarp in HP‐200 on monoaminergic neurotransmitters and its metabolite in various regions of the rat brain. HP‐200 at a dose of 2.5, 5.0 or 10.0 g/kg/day was mixed with rat chow and fed daily __ad lib__ to Sprague‐Dawley rats (__n__ = 6 for each group) for 52 weeks. Controls (__n__ = 6) received no drug. Random assignment was made for doses and control. The rats were sacrificed at the end of 52 weeks and the neurotransmitters were analyzed in the cortex, hippocampus, substantia nigra and striatum. Oral administration of __Mucuna pruriens__ endocarp in the form of HP‐200 had a significant effect on dopamine content in the cortex with no significant effect on levodopa, norepinephrine or dopamine, serotonin, and their metabolites‐ HVA, DOPAC and 5‐HIAA in the nigrostriatal tract. The failure of __Mucuna pruriens__ endoca

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Author

Bala V. Manyam; Muralikrishnan Dhanasekaran; Theodore A. Hare

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)