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Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT by Jessica Winne; Barbara C. Boerner; Thawann Malfatti; Elis Brisa; Jhulimar Doerl; Ingrid Nogueira; Katarina E. Leão; Richardson N. Leão is a Neuroscience article available to read on EtoBox.

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Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect. Using microwire electrode arrays, we recorded local field potential in young (4-5- month-old) and old (11-13-month-old) mice to study the electrophysiological effect of tinnitus in the ventral hippocampus (vHipp) and medial prefrontal cortex (mPFC) in an open field arena and elevated plus maze 1h after salicylate (300mg/kg) injection. We found that anxiety-like behavior and increase in theta2 oscillations (4-6 Hz), following salicylate pre-treatment, only occurs in young (normal hearing) mice. We also show that theta2 and slow gamma oscillations increase in the vHipp and mPFC in a complementary manner during anxiety tests in the presence of salicylate. Finally, we show that pre-treating mice with a single dose of the hallucinogenic 5-MeO-DMT prevents anxiety-like behavior an

Who reads Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT?

Author

Jessica Winne; Barbara C. Boerner; Thawann Malfatti; Elis Brisa; Jhulimar Doerl; Ingrid Nogueira; Katarina E. Leão; Richardson N. Leão

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)