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Can I read Development and Evaluation of Finasteride Niosomes Targeting to Hair Follicles for the Management of Androgenic Alopecia on EtoBox?
Development and Evaluation of Finasteride Niosomes Targeting to Hair Follicles for the Management of Androgenic Alopecia by Xiang Liu; Feng Guo; Desheng Liang; Zilin Li; Yating Cao; Mengqi Chen; Jianjun Xu; Xinliang Liu; Haijun Zhong is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Development and Evaluation of Finasteride Niosomes Targeting to Hair Follicles for the Management of Androgenic Alopecia about?
Finasteride, a selective Type II 5α-reductase inhibitor, has been approved as an oral drug for the treatment and prevention of androgenetic alopecia (AGA). The daily administration of finasteride by oral route may lead to various undesirable systemic side effects. In the present study, finasteride niosomes (FIN-NIS) as a dermal topical delivery system were developed evaluated in vitro/in vivo in an attempt to overcome the limitations of the oral administration of finasteride, enhance the retention of finasteride into hair follicles, and cause fewer adverse effects. FIN-NIS were prepared by ethanol injection method and characterized for particle size, entrapment efficiency (EE), in vitro release and in vitro skin retention. Testosterone-induced AGA mice model was used to evaluate the therapeutic effect of FIN-NIS. The results show that the particle size of FIN-NIS was about 260 nm with a good loading capacity, and the EE was greater than 90%. FIN-NIS had the sustained-release effect to some extent. Compared with the hydroethanolic solution of finasteride (FIN-hydroethanol) and finasteride suspension (FIN-suspension), FIN-NIS showed higher drug concentration in the excised rat skin,
Who reads Development and Evaluation of Finasteride Niosomes Targeting to Hair Follicles for the Management of Androgenic Alopecia?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Xiang Liu; Feng Guo; Desheng Liang; Zilin Li; Yating Cao; Mengqi Chen; Jianjun Xu; Xinliang Liu; Haijun Zhong
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)