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Can I read Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene on EtoBox?
Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene by So Hata; A.Hajime Koyama; Hiroshi Shiota; Akio Adachi; Fumi Goshima; Yukihiro Nishiyama is a Medicine article available to read on EtoBox.
What is Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene about?
In order to determine the ability of herpes simplex virus type 2 (HSV-2) to suppress apoptosis, we examined the effect of HSV-2 infection on apoptosis induced in HEp-2 cells by treatment with 1 M sorbitol. Although a wild-type strain of HSV-2 induced apoptosis in a significant fraction of the infected cells, HSV-2 could suppress sorbitol-induced apoptosis in a manner similar to that of herpes simplex virus type 1 (HSV-1), indicating that HSV-2, like HSV-1, has an antiapoptosis gene. Characterization of the cells infected with a US3-deletion mutant of HSV-2 revealed the necessity of a US3 gene in the antiapoptotic activity of this virus.
Who reads Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- So Hata; A.Hajime Koyama; Hiroshi Shiota; Akio Adachi; Fumi Goshima; Yukihiro Nishiyama
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Life Sciences)