Can I read Transient and durable T cell reactivity after COVID-19 on EtoBox?

Transient and durable T cell reactivity after COVID-19 by Anna Martner; Hanna Grauers Wiktorin; Andreas Törnell; Johan Ringlander; Mohammad Arabpour; Magnus Lindh; Martin Lagging; Staffan Nilsson; Kristoffer Hellstrand is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Transient and durable T cell reactivity after COVID-19 about?

This study analyzed whole blood samples (__n__ = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until ∼70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-γ remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein. These results unravel two phases of T cell reactivity following natural COVID-19: an early, synchronous response indicating transient presence of multipolar, antigen-specific T helper (T~H~) cells followed by an equally synchronous and durable T~H~1-like reactivity reflecting long-lasting T cell memory.

Who reads Transient and durable T cell reactivity after COVID-19?

Author

Anna Martner; Hanna Grauers Wiktorin; Andreas Törnell; Johan Ringlander; Mohammad Arabpour; Magnus Lindh; Martin Lagging; Staffan Nilsson; Kristoffer Hellstrand

Publisher

Proceedings of the National Academy of Sciences

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)