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Continuously released Zn^2+^ in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties by Chunxu Li; Fengbo Sun; Jingjing Tian; Jiahao Li; Haidan Sun; Yong Zhang; Shigong Guo; Yuanhua Lin; Xiaodan Sun; Yu Zhao is a Engineering article available to read on EtoBox.
What is Continuously released Zn^2+^ in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties about?
Long-term nonunion of bone defects has always been a major problem in orthopedic treatment. Artificial bone graft materials such as Poly (lactic-co-glycolic acid)/β-tricalcium phosphate (PLGA/β-TCP) scaffolds are expected to solve this problem due to their suitable degradation rate and good osteoconductivity. However, insufficient mechanical properties, lack of osteoinductivity and infections after implanted limit its large-scale clinical application. Hence, we proposed a novel bone repair bioscaffold by adding zinc submicron particles to PLGA/β-TCP using low temperature rapid prototyping 3D printing technology. We first screened the scaffolds with 1 wt% Zn that had good biocompatibility and could stably release a safe dose of zinc ions within 16 weeks to ensure long-term non-toxicity. As designed, the scaffold had a multi-level porous structure of biomimetic cancellous bone, and the Young's modulus (63.41 ± 1.89 MPa) and compressive strength (2.887 ± 0.025 MPa) of the scaffold were close to those of cancellous bone. In addition, after a series of __in vitro__ and __in vivo__ experiments, the scaffolds proved to have no adverse effects on the viability of BMSCs and promoted their a
Who reads Continuously released Zn^2+^ in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Chunxu Li; Fengbo Sun; Jingjing Tian; Jiahao Li; Haidan Sun; Yong Zhang; Shigong Guo; Yuanhua Lin; Xiaodan Sun; Yu Zhao
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)