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Withania Somnifera Root Extract Inhibits Fatty Acid Synthesis in Prostate Cancer Cells by Su-Hyeong Kim; Krishna B. Singh; Eun-Ryeong Hahm; Balakrishna L. Lokeshwar; Shivendra V. Singh is a Medicine article available to read on EtoBox.

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Prior research argues for a role of increased __de novo__ fatty acid synthesis in pathogenesis of prostate adenocarcinoma, which remains a leading cause of cancer-associated mortality in American men. A safe and effective inhibitor of fatty acid synthesis is still a clinically unmet need. Herein, we investigated the effect of ethanol extract of __Withania somnifera__ root (WRE) standardized for one of its components (withaferin A) on fatty acid synthesis using LNCaP and 22Rv1 human prostate cancer cells. __Withania somnifera__ is a medicinal plant used in the Ayurvedic medicine practiced in India. Western blotting and confocal microscopy revealed a statistically significant decrease in protein levels of key fatty acid metabolism enzymes including ATP citrate lyase (ACLY), acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FASN), and carnitine palmitoyltransferase 1A (CPT1A) in WRE-treated cells compared with solvent control. The mRNA levels of __ACLY__, __ACC1__, __FASN__, and __CPT1A__ were also lower in WRE-treated cells in comparison with control. Consequently, WRE treatment resulted in a significant decrease in intracellular levels of acetyl-CoA, total free fatty acids, and

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Author

Su-Hyeong Kim; Krishna B. Singh; Eun-Ryeong Hahm; Balakrishna L. Lokeshwar; Shivendra V. Singh

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)