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A Conductive Nanostructured Polymer Electrodeposited on Titanium as a Controllable, Local Drug Delivery Platform by Sirinrath Sirivisoot; Rajesh A. Pareta; Thomas J. Webster is a Engineering article available to read on EtoBox.

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## Abstract Infection and inflammation associated with orthopedic implants can be life threatening, time consuming, and expensive, thus, motivating the development of a local drug delivery platform that could prevent such deleterious events. For this purpose, nanostructured polypyrrole (PPy) incorporating antibiotics and anti‐inflammatory drugs (penicillin/streptomycin (P/S) or dexamethasone (Dex), respectively) were coated on commercially pure titanium through an easy to use electrochemical deposition method. As shown in our previous study, about 80% (compared with initial amount) of these incorporated drugs were released after electrical stimulation spanning five cycles (voltage was varied between −1 V and 1 V). In a further continuation of this work, nanostructured P/S incorporated PPy coatings on titanium were demonstrated to be bactericidal against __Staphylococcus epidermis__ after 1 h, and when incorporated with Dex, inhibited macrophage (an inflammatory and immune response cell) growth after 8 and 13 h of __in vitro__ culture. Moreover, nanostructured PPy‐drug films coated on titanium enhanced osteoblast (bone forming cells) proliferation, while at the same time, suppressed

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Author

Sirinrath Sirivisoot; Rajesh A. Pareta; Thomas J. Webster

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)