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P53 Codon 72 Polymorphisms in Human Papillomavirus‐negative and Human Papillomavirus‐positive Squamous Cell Carcinomas of the Oropharynx by Federica Perrone; Luigi Mariani; Elisa Pastore; Marta Orsenigo; Simona Suardi; Barbara Marcomini; Luca DaRiva; Lisa Licitra; Antonino Carbone; Marco A. Pierotti; Silvana Pilotti is a Medicine article available to read on EtoBox.

What is P53 Codon 72 Polymorphisms in Human Papillomavirus‐negative and Human Papillomavirus‐positive Squamous Cell Carcinomas of the Oropharynx about?

## Abstract ## BACKGROUND. Tobacco smoking, alcohol abuse, and high‐risk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The __TP53__ polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect. ## METHODS. The aim of the study was to investigate the role of codon 72 polymorphism by means of double gradient‐denaturing gel electrophoresis in 77 oropharyngeal SCC patients including 33 __TP53__ mutated and 16 HPV‐16‐positive cases. The controls consisted of 141 consecutive healthy blood donors. ## RESULTS. The cases and controls showed significantly different genotype distribution (__P__ = .0005): the frequencies of the RR, RP, and PP genotypes among the cases were, respectively, 81.8%, 10.4%, and 7.8%, as opposed to 59.6%, 33.3%, and 7.1% among the controls, in agreement with the Hardy‐Weinberg equilibrium (__P__ = .35). The PP genotype was significantly overrepresented among females (22.2% vs 3.4%; __P__ = .0243) and in HPV‐16‐positive cases (25.0% vs 3.3%; __P__ = .0152). No segregation was found between either of the codon

Who reads P53 Codon 72 Polymorphisms in Human Papillomavirus‐negative and Human Papillomavirus‐positive Squamous Cell Carcinomas of the Oropharynx?

Author

Federica Perrone; Luigi Mariani; Elisa Pastore; Marta Orsenigo; Simona Suardi; Barbara Marcomini; Luca DaRiva; Lisa Licitra; Antonino Carbone; Marco A. Pierotti; Silvana Pilotti

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2007

Language

EN

Field

Medicine (Health Sciences)