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Automatic repositioning of single voxels in longitudinal ^1^H MRS studies by Ileana Hancu; Daniel J. Blezek; Michelle C. Dumoulin is a Medicine article available to read on EtoBox.

What is Automatic repositioning of single voxels in longitudinal ^1^H MRS studies about?

## Abstract An automatic procedure, allowing the prospective registration of brain MRI images and the acquisition of nearly identical brain volumes (coverage and orientation) in longitudinal exams, is presented. This procedure, based on a fast registration algorithm and a tailored pulse sequence, is used to reposition single voxels for ^1^H MRS data acquired __in vivo__. The impact of the repositioning method on the extent of voxel overlap and on the reproducibility of metabolite concentration measurements is studied. A statistically significant increase in voxel overlap and generally decreased short‐term measurement variability (decreased coefficients of variation and increased reproducibility coefficients) are observed. Differences in the long‐term variances of metabolite concentrations and concentration ratios measured using the eye and automatic repositioning scheme, however, do not reach statistical significance. The improved workflow associated with the use of the automatic repositioning process, which obviates the need for skilled operator intervention for voxel repositioning, suggests that approaches similar to the one presented here may be a standard element in tomorrow's

Who reads Automatic repositioning of single voxels in longitudinal ^1^H MRS studies?

Author

Ileana Hancu; Daniel J. Blezek; Michelle C. Dumoulin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3480)

Published

2005

Language

EN

Field

Medicine (Health Sciences)