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Splenectomy During Partial Remission in Thrombotic Thrombocytopenic Purpura with Prolonged Plasma Exchange Dependency by Mant, Michael J.; Turner, A. Robert; Bruce, D.; Ritchie, C.; Larratt, Loree M. is a Medicine article available to read on EtoBox.

What is Splenectomy During Partial Remission in Thrombotic Thrombocytopenic Purpura with Prolonged Plasma Exchange Dependency about?

Some patients with thrombotic thrombocytopenic purpura (TTP) remain plasmaexchange-dependent for prolonged periods of time. This exposes patients to risk, uses substantial resources, and requires prolonged hospitalization. We have splenectomized 7 such patients following 25-42 plasma exchanges while patients were in partial remission only and were clinically stable. In 6 patients, including 1 with TTP secondary to mitomycin C, thrombocytopenia promptly resolved. Relapse has not occurred during 18 or more months of observation. The seventh patient did not respond. We conclude that splenectomy should be considered as an alternative to continued plasma-exchange therapy in such patients. Am.

Who reads Splenectomy During Partial Remission in Thrombotic Thrombocytopenic Purpura with Prolonged Plasma Exchange Dependency?

Author

Mant, Michael J.; Turner, A. Robert; Bruce, D.; Ritchie, C.; Larratt, Loree M.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

1999

Language

EN

Field

Medicine (Health Sciences)