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Role of TGF-β in oncogenesis by Michael Weller; W. Wick; M. Platten is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Role of TGF-␤ in Oncogenesis Transforming growth factor-␤ (TGF-␤) is the founding member of a large and growing family of growth factors with regulatory properties of a multitude of cellular processes including cell proliferation, differentiation, motility, adhesion, and death. Given this multifunctional nature of TGF-␤, it is not surprising that during the past two decades researchers have discovered that TGF-␤ is an important factor involved in the genesis of cancers of various origin. This special issue is dedicated to the emerging role of TGF-␤ in oncogenesis. The function of TGF-␤ in cancer biology is rather complex since it appears that TGF-␤ acts as a growth inhibitor in the early stages of tumorigenesis but may promote tumor growth at later stages. This is not unexpected, keeping in mind that TGF-␤ acts on virtually every cell type in the body and that tumor growth is a result of a complex tumor-host-interaction. Thus, specificity of signaling can only be achieved by complex processing and signaling events. Hence, the first review by K. Koli et al. focusses on the cellular and extracellular mechanisms underlying the processing of active TGF-␤ from latent complexes. These

Who reads Role of TGF-β in oncogenesis?

Author

Michael Weller; W. Wick; M. Platten

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1059-910X)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)