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Can I read New Insights Into the T-complex and Control of Sperm Function on EtoBox?
New Insights Into the T-complex and Control of Sperm Function by Lynn R. Fraser; Keith Dudley is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is New Insights Into the T-complex and Control of Sperm Function about?
The mouse t-complex, located on chromosome 17, contains genes known to influence male, but not female, fertility. Although some t-complex genes are recessive lethals, t-chromosomes are maintained in the population by transmission ratio distortion. When male mice heterozygous for the t-chromosome mate with wild-type females, most offspring will possess the t-chromosome, indicating a link between t-complex genes and sperm function. Several proteins coded for by t-complex genes have been localised in the sperm flagellum, suggesting roles relating to motility. Another t-complex protein appears able to regulate the adenylyl cyclase/cAMP signal transduction pathway, known to play an important role in capacitation. Defective motility and/or failure to capacitate (''switch on'') would result in poorly fertile or infertile spermatozoa. Given the existence of human homologues for many genes in the t-complex and the prevalence of ''male factor'' infertility, information obtained about the t-complex not only will provide insight into basic biological mechanisms but may be of future clinical relevance as well.
Who reads New Insights Into the T-complex and Control of Sperm Function?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lynn R. Fraser; Keith Dudley
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)