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This study investigates the expression of mineralization-regulating proteins in human peripheral arteries affected by Mönckeberg’s sclerosis (MS), a form of vascular calcification prevalent in aged and diabetic individuals. The findings suggest that vascular smooth muscle cells (VSMCs) in MS lesions exhibit osteoblastic properties and altered gene expression, indicating that medial calcification is an active and regulated process. The research highlights the potential role of modified VSMCs in orchestratin

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kimhyunra1l7

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