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Antiproliferative Bromo-Tyramine from Aplysina by valeria.costantino2019 is a document available to read on EtoBox.
This study presents a bioassay-guided procedure combined with high-resolution electrospray ionization mass spectrometry (HR-ESIMS) to isolate the antiproliferative compound N,N,N-trimethyl-3,5-dibromotyramine from the marine sponge Aplysina cauliformis. The compound demonstrated significant cytotoxic effects on HepG2 cell lines with an IC50 value of 37.49±1.94 μg/mL, inducing apoptosis through the upregulation of pro-apoptotic markers. The findings highlight the potential of marine-derived compounds in canc
- Author
- valeria.costantino2019
- Language
- EN