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Phase III Study Comparing Prone Accelerated Whole Breast IMRT with a Daily vs. a Weekly Tumor Bed Boost: Interim Analysis Results by S.C. Lymberis; M. Fenton-Kerimian; C. Buck; B.S. Rosenstein; K. DeWyngaert; J. Goldberg; S.C. Formenti is a Medicine article available to read on EtoBox.

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of younger age, larger tumor size, greater # of nodes positive, % of nodes positive, $ 4 nodes, and ECE. Patient characteristics on UVA associated with a statistically significant increased risk for regional recurrence (p # 0.05) were age # 35 years 4%, NX 3.9%, ECE 2.1%, grade 3 2.4%, LVI 2.9%, and chemotherapy without hormones 2.6%. On MVA of all patients, only age # 35 years (p = 0.04) and LVI (p = 0.03) were independent predictors for regional node recurrence. Subgroup analysis of patients treated to the regional nodes was done. Patients treated with an axillary boost in addition to a supraclavicular field more often had an undissected axilla (p = 0.02) or . 75% of nodes positive (p = 0.05) compared to patients treated with a supraclavicular field alone. On MVA, the 10-year regional recurrence rate was 4% for patients treated with a supraclavicular field only, compared to 0.5% for supraclavicular and axillary boost (p = 0.02). Conclusions: The risk of regional recurrence was very low in this large series of patients treated with BCT and adjuvant radiation. Age # 35 years and LVI are independent predictors for increased regional recurrence. The use of an axillary boost was assoc

Who reads Phase III Study Comparing Prone Accelerated Whole Breast IMRT with a Daily vs. a Weekly Tumor Bed Boost: Interim Analysis Results?

Author

S.C. Lymberis; M. Fenton-Kerimian; C. Buck; B.S. Rosenstein; K. DeWyngaert; J. Goldberg; S.C. Formenti

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)