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Best practice: antibiotic decision-making in ICUs by Adrian John Brink; Guy Richards is a scholarly article available to read on EtoBox.

What is Best practice: antibiotic decision-making in ICUs about?

## Purpose of review: A major challenge in the icu is optimization of antibiotic use. this review assesses current understanding of core best practices supporting and promoting astute antibiotic decision-making. ## Recent findings: Limiting exposure to the shortest effective duration is the cornerstone of antibiotic decision-making. the decision to initiate antibiotics should include assessment of risk for resistance. this requires synthesis of patient-level data and environmental factors to determine whether delayed initiation could be considered in some patients with suspected sepsis until sensitivity data is available. until improved stratification scores and clinically meaningful cut-off values to identify mdr are available and externally validated, decisions as to which empiric antibiotic is used should rely on syndromic antibiograms and institutional guidance. optimization of initial and maintenance doses is another enabler of enhanced outcome. stewardship practices must be streamlined by re-assessment to minimize negative effects, such as a potential increase in duration of therapy and increased risk of collateral damage from exposure to multiple, sequential antibiotics that

Author

Adrian John Brink; Guy Richards

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN