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The role of K^+^ and H^+^ transport systems during glucose‐ and H~2~O~2~‐induced cell death in Saccharomyces cerevisiae by Frank A. Hoeberichts; Jorge Perez-Valle; Consuelo Montesinos; José M. Mulet; María D. Planes; Guillem Hueso; Lynne Yenush; Sukesh C. Sharma; Ramón Serrano is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The role of K^+^ and H^+^ transport systems during glucose‐ and H~2~O~2~‐induced cell death in Saccharomyces cerevisiae about?
## Abstract Glucose, in the absence of additional nutrients, induces programmed cell death in yeast. This phenomenon is independent of yeast metacaspase (Mca1/Yca1) and of calcineurin, requires ROS production and it is concomitant with loss of cellular K^+^ and vacuolar collapse. K^+^ is a key nutrient protecting the cells and this effect depends on the Trk1 uptake system and is associated with reduced ROS production. Mutants with decreased activity of plasma membrane H^+^‐ATPase are more tolerant to glucose‐induced cell death and exhibit less ROS production. A triple mutant __ena1‐4 tok1 nha1__, devoid of K^+^ efflux systems, is more tolerant to both glucose‐ and H~2~O~2~‐induced cell death. We hypothesize that ROS production, activated by glucose and H^+^‐ATPase and inhibited by K^+^ uptake, triggers leakage of K^+^, a process favoured by K^+^ efflux systems. Loss of cytosolic K^+^ probably causes osmotic lysis of vacuoles. The nature of the ROS‐producing system sensitive to K^+^ and H^+^ transport is unknown. Copyright © 2010 John Wiley & Sons, Ltd.
Who reads The role of K^+^ and H^+^ transport systems during glucose‐ and H~2~O~2~‐induced cell death in Saccharomyces cerevisiae?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Frank A. Hoeberichts; Jorge Perez-Valle; Consuelo Montesinos; José M. Mulet; María D. Planes; Guillem Hueso; Lynne Yenush; Sukesh C. Sharma; Ramón Serrano
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)