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This study investigates the molecular mechanisms by which the SARS-CoV-2 spike protein engages with the ACE2 receptor, leading to proteolytic cleavage at the S20 site and subsequent membrane fusion. The findings reveal that the cleavage at the S20 site, particularly at arginine 815, is essential for the formation of syncytia and viral infection across various SARS-CoV-2 variants. This research highlights the importance of receptor engagement and S20 cleavage as potential targets for antiviral strategies aga

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ravena.maia

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EN