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Can I read Plasma‐activated medium as an innovative anticancer strategy: Insight into its cellular and molecular impact on in vitro leukemia cells on EtoBox?
Plasma‐activated medium as an innovative anticancer strategy: Insight into its cellular and molecular impact on in vitro leukemia cells by Eleonora Turrini; Romolo Laurita; Emanuele Simoncelli; Augusto Stancampiano; Elena Catanzaro; Cinzia Calcabrini; Giovanni Carulli; Martina Rousseau; Matteo Gherardi; Francesca Maffei; Veronica Cocchi; Monia Lenzi; Valentina Pellicioni; Patrizia Hrelia; Vittorio Colombo; Carmela Fimognari is a Engineering article available to read on EtoBox.
What is Plasma‐activated medium as an innovative anticancer strategy: Insight into its cellular and molecular impact on in vitro leukemia cells about?
## Abstract Cold atmospheric plasma (CAP) has received attention as a potential anticancer strategy. In this study, culture medium was exposed to a microsecond‐pulsed dielectric barrier discharge jet to produce plasma‐activated medium (PAM). On the T‐lymphoblastic cell line, PAM induced apoptosis through the activation of the intrinsic pathway and inhibited the cell‐cycle progression. The use of the scavengers N‐acetylcysteine or O‐phenantroline significantly decreased the PAM proapoptotic activity. The genetic impact of PAM on TK6 cells was assessed, resulting in an increased micronuclei frequency. PAM exhibited cytotoxic effects even on leukemia cells cultivated in hypoxia, which plays a critical role in promoting chemoresistance. PAM was also tested on normal lymphocytes, showing its partial selectivity. Taken together, these results contribute to understand the pharmacotoxicological profile of CAP.
Who reads Plasma‐activated medium as an innovative anticancer strategy: Insight into its cellular and molecular impact on in vitro leukemia cells?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Eleonora Turrini; Romolo Laurita; Emanuele Simoncelli; Augusto Stancampiano; Elena Catanzaro; Cinzia Calcabrini; Giovanni Carulli; Martina Rousseau; Matteo Gherardi; Francesca Maffei; Veronica Cocchi; Monia Lenzi; Valentina Pellicioni; Patrizia Hrelia; Vittorio Colombo; Carmela Fimognari
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 1612-8850)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)