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Glanzmann Thrombasthenia is a rare autosomal recessive bleeding disorder caused by GPIIb/IIIa deficiency, with a prevalence of approximately 1 in 1,000,000, particularly affecting consanguineous populations. It leads to impaired platelet aggregation despite normal platelet counts, resulting in symptoms such as easy bruising, nosebleeds, and severe bleeding in some cases. Management includes acute bleeding measures, platelet transfusions, and emerging therapies like gene therapy and monoclonal antibodies.

Author

MohamedHossam

Language

EN