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Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia by Jing-Yi Shi; Zhi-Hong Ren; Bo Jiao; Run Xiao; Hai-Yang Yun; Bing Chen; Wei-Li Zhao; Qi Zhu; Zhu Chen; Sai-Juan Chen is a Medicine article available to read on EtoBox.
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## Abstract Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we analyzed 42 genetic variations among 15 candidate genes in 307 AML patients and 560 age‐sex matched controls. Their associations with chemotherapy response were further evaluated in combination with other well‐established prognostic factors. An increased risk of AML was found in individuals heterozygous for __XPD__ 2251A>C (rs13181) with an odds ratio (OR) of 1.637 (95% confidence interval [CI]: 1.118–2.395), and the increased risk could be attributed to C allele (OR = 1.505, 95% CI: 1.061–2.134). Postchemotherapy response analysis revealed that AML patients heterozygous for __ATM__ 4138C>T (rs3092856) or GG homozygous for __TP53__ 215C>G (rs1042522) were independently linked to inferior treatment outcomes. These results uncover novel prognostic factors for AML patients treated with chemotherapy and may also indicate an etiological role of __XPD__ in this
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- Author
- Jing-Yi Shi; Zhi-Hong Ren; Bo Jiao; Run Xiao; Hai-Yang Yun; Bing Chen; Wei-Li Zhao; Qi Zhu; Zhu Chen; Sai-Juan Chen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)