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Evaluation of Serological Lateral Flow Assays for Severe Acute Respiratory Syndrome Coronavirus-2 by Trombetta, Bianca A. (author);Kandigian, Savannah E. (author);Kitchen, Robert R. (author);Grauwet, Korneel (author);Webb, Pia Kivisäkk (author);Miller, Glenn A. (author);Jennings, Charles G. (author);Jain, Sejal (author);Miller, Samara (author);Kuo, Yikai (author);Sweeney, Thadryan (author);Gilboa, Tal (author);Norman, Maia (author);Simmons, Daimon P. (author);Ramirez, Christopher E. (author);Bedard, Melissa (author);Fink, Catherine (author);Ko, Jina (author);De León Peralta, Esmarline J. (author);Watts, Gerald (author);Gomez-Rivas, Emma (author);Davis, Vannessa (author);Barilla, Rocky M. (author);Wang, Jianing (author);Cunin, Pierre (author);Bates, Samuel (author);Morrison-Smith, Chevaun (author);Nicholson, Benjamin (author);Wong, Edmond (author);El-Mufti, Leena (author);Kann, Michael (author);Bolling, Anna (author);Fortin, Brooke (author);Ventresca, Hayden (author);Zhou, Wen (author);Pardo, Santiago (author);Kwock, Megan (author);Hazra, Aditi (author);Cheng, Leo (author);Ahmad, Q. Rushdy (author);Toombs, James A. (author);Larson, Rebecca (author);Pleskow, Haley (author);Luo, Nell Meosky (author);Samaha, Christina (author);Pandya, Unnati M. (author);De Silva, Pushpamali (author);Zhou, Sally (author);Ganhadeiro, Zakary (author);Yohannes, Sara (author);Gay, Rakiesha (author);Slavik, Jacqueline (author);Mukerji, Shibani S. (author);Jarolim, Petr (author);Walt, David R. (author);Carlyle, Becky C. (author);Ritterhouse, Lauren L. (author);Suliman, Sara (author) is a scholarly article available to read on EtoBox.

What is Evaluation of Serological Lateral Flow Assays for Severe Acute Respiratory Syndrome Coronavirus-2 about?

## Background COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized evaluation of their accuracy and tools to aid in interpreting results are needed. ## Methods We evaluated 20 IgG and IgM assays selected from available tests in April 2020. We evaluated the assays’ performance using 56 pre-pandemic negative and 56 SARS-CoV-2-positive plasma samples, collected 10–40 days after symptom onset, confirmed by a molecular test and analyzed by an ultra-sensitive immunoassay. Finally, we developed a user-friendly web app to extrapolate the positive predictive values based on their accuracy and local prevalence. ## Results Combined IgG + IgM sensitivities ranged from 33.9 to 94.6%, while combined specificities ranged from 92.6 to 100%. The highest sensitivities were detected in Lumiquick for IgG (98.2%), BioHit for both IgM (96.4%), and combined IgG + IgM sensitivity (94.6%). Furthermore, 11 LFAs and 8 LFAs showed perfect specificity for IgG and IgM, respectively, with 15 LFAs showing perfect combined IgG + IgM specificit

Author
Trombetta, Bianca A. (author);Kandigian, Savannah E. (author);Kitchen, Robert R. (author);Grauwet, Korneel (author);Webb, Pia Kivisäkk (author);Miller, Glenn A. (author);Jennings, Charles G. (author);Jain, Sejal (author);Miller, Samara (author);Kuo, Yikai (author);Sweeney, Thadryan (author);Gilboa, Tal (author);Norman, Maia (author);Simmons, Daimon P. (author);Ramirez, Christopher E. (author);Bedard, Melissa (author);Fink, Catherine (author);Ko, Jina (author);De León Peralta, Esmarline J. (author);Watts, Gerald (author);Gomez-Rivas, Emma (author);Davis, Vannessa (author);Barilla, Rocky M. (author);Wang, Jianing (author);Cunin, Pierre (author);Bates, Samuel (author);Morrison-Smith, Chevaun (author);Nicholson, Benjamin (author);Wong, Edmond (author);El-Mufti, Leena (author);Kann, Michael (author);Bolling, Anna (author);Fortin, Brooke (author);Ventresca, Hayden (author);Zhou, Wen (author);Pardo, Santiago (author);Kwock, Megan (author);Hazra, Aditi (author);Cheng, Leo (author);Ahmad, Q. Rushdy (author);Toombs, James A. (author);Larson, Rebecca (author);Pleskow, Haley (author);Luo, Nell Meosky (author);Samaha, Christina (author);Pandya, Unnati M. (author);De Silva, Pushpamali (author);Zhou, Sally (author);Ganhadeiro, Zakary (author);Yohannes, Sara (author);Gay, Rakiesha (author);Slavik, Jacqueline (author);Mukerji, Shibani S. (author);Jarolim, Petr (author);Walt, David R. (author);Carlyle, Becky C. (author);Ritterhouse, Lauren L. (author);Suliman, Sara (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN

More by Trombetta, Bianca A. (author);Kandigian, Savannah E. (author);Kitchen, Robert R. (author);Grauwet, Korneel (author);Webb, Pia Kivisäkk (author);Miller, Glenn A. (author);Jennings, Charles G. (author);Jain, Sejal (author);Miller, Samara (author);Kuo, Yikai (author);Sweeney, Thadryan (author);Gilboa, Tal (author);Norman, Maia (author);Simmons, Daimon P. (author);Ramirez, Christopher E. (author);Bedard, Melissa (author);Fink, Catherine (author);Ko, Jina (author);De León Peralta, Esmarline J. (author);Watts, Gerald (author);Gomez-Rivas, Emma (author);Davis, Vannessa (author);Barilla, Rocky M. (author);Wang, Jianing (author);Cunin, Pierre (author);Bates, Samuel (author);Morrison-Smith, Chevaun (author);Nicholson, Benjamin (author);Wong, Edmond (author);El-Mufti, Leena (author);Kann, Michael (author);Bolling, Anna (author);Fortin, Brooke (author);Ventresca, Hayden (author);Zhou, Wen (author);Pardo, Santiago (author);Kwock, Megan (author);Hazra, Aditi (author);Cheng, Leo (author);Ahmad, Q. Rushdy (author);Toombs, James A. (author);Larson, Rebecca (author);Pleskow, Haley (author);Luo, Nell Meosky (author);Samaha, Christina (author);Pandya, Unnati M. (author);De Silva, Pushpamali (author);Zhou, Sally (author);Ganhadeiro, Zakary (author);Yohannes, Sara (author);Gay, Rakiesha (author);Slavik, Jacqueline (author);Mukerji, Shibani S. (author);Jarolim, Petr (author);Walt, David R. (author);Carlyle, Becky C. (author);Ritterhouse, Lauren L. (author);Suliman, Sara (author)

Browse all works by Trombetta, Bianca A. (author);Kandigian, Savannah E. (author);Kitchen, Robert R. (author);Grauwet, Korneel (author);Webb, Pia Kivisäkk (author);Miller, Glenn A. (author);Jennings, Charles G. (author);Jain, Sejal (author);Miller, Samara (author);Kuo, Yikai (author);Sweeney, Thadryan (author);Gilboa, Tal (author);Norman, Maia (author);Simmons, Daimon P. (author);Ramirez, Christopher E. (author);Bedard, Melissa (author);Fink, Catherine (author);Ko, Jina (author);De León Peralta, Esmarline J. (author);Watts, Gerald (author);Gomez-Rivas, Emma (author);Davis, Vannessa (author);Barilla, Rocky M. (author);Wang, Jianing (author);Cunin, Pierre (author);Bates, Samuel (author);Morrison-Smith, Chevaun (author);Nicholson, Benjamin (author);Wong, Edmond (author);El-Mufti, Leena (author);Kann, Michael (author);Bolling, Anna (author);Fortin, Brooke (author);Ventresca, Hayden (author);Zhou, Wen (author);Pardo, Santiago (author);Kwock, Megan (author);Hazra, Aditi (author);Cheng, Leo (author);Ahmad, Q. Rushdy (author);Toombs, James A. (author);Larson, Rebecca (author);Pleskow, Haley (author);Luo, Nell Meosky (author);Samaha, Christina (author);Pandya, Unnati M. (author);De Silva, Pushpamali (author);Zhou, Sally (author);Ganhadeiro, Zakary (author);Yohannes, Sara (author);Gay, Rakiesha (author);Slavik, Jacqueline (author);Mukerji, Shibani S. (author);Jarolim, Petr (author);Walt, David R. (author);Carlyle, Becky C. (author);Ritterhouse, Lauren L. (author);Suliman, Sara (author)