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ZnO–DOX@ZIF-8 Core–Shell Nanoparticles for pH-Responsive Drug Delivery by Cunchuan Zheng; Yang Wang; Soo Zeng Fiona Phua; Wei Qi Lim; Yanli Zhao is a Engineering article available to read on EtoBox.

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Developing multifunctional hybrid nanosystems for controlled drug delivery is a challenging task. In this work, we prepared hierarchical core-shell nanoparticles (ZnO-DOX@ZIF-8) composed of mesoporous ZnO core and microporous ZIF-8 shell, in which the core serves as the drug storage reservoir for the loading of anticancer drug doxorubicin (DOX) and the shell could be used to prevent premature release of loaded drug at physiological environment. The mesoporous ZnO nanoparticles were first prepared, followed by DOX drug loading. Such ZnO nanoparticles were then employed as the zinc source to react with 2-methylimidazole for the formation of ZnO-DOX@ZIF-8 core-shell nanoparticles. The core-shell nanoparticles exhibit good dispersibility and stability as well as pH-responsive drug release property. While only up to 20% of loaded DOX was released in the buffer of pH 7.4, over 80% of DOX was released in the buffer of pH 5.5 because of the decomposition of the ZIF-8 shell as well as the dissolution of the ZnO core under acidic conditions. The confocal microscopy studies show that the core-shell nanoparticles could be efficiently internalized by cancer cells, and the loaded DOX in the nano

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Author

Cunchuan Zheng; Yang Wang; Soo Zeng Fiona Phua; Wei Qi Lim; Yanli Zhao

Publisher

American Chemical Society (ACS)

Published

2017

Language

EN

Field

Engineering (Physical Sciences)