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Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses by Sergei A. Raev; Molly Raque; Maryssa K. Kick; Linda J. Saif; Anastasia N. Vlasova is a Medicine article available to read on EtoBox.

What is Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses about?

## Background Rotavirus C (RVC) is the major causative agent of acute gastroenteritis in suckling piglets, while most RVAs mostly affect weaned animals. Besides, while most RVA strains can be propagated in MA-104 and other continuous cell lines, attempts to isolate and culture RVC strains remain largely unsuccessful. The host factors associated with these unique RVC characteristics remain unknown. ## Methods In this study, we have comparatively evaluated transcriptome responses of porcine ileal enteroids infected with RVC G1P[1] and two RVA strains (G9P[13] and G5P[7]) with a focus on innate immunity and virus-host receptor interactions. ## Results The analysis of differentially expressed genes regulating antiviral immune response indicated that in contrast to RVA, RVC infection resulted in robust upregulation of expression of the genes encoding pattern recognition receptors including RIG1-like receptors and melanoma differentiation-associated gene-5. RVC infection was associated with a prominent upregulation of the most of glycosyltransferase-encoding genes except for the sialyltransferase-encoding genes which were downregulated similar to the effects observed for G9P[13]. ## Conc

Who reads Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses?

Author

Sergei A. Raev; Molly Raque; Maryssa K. Kick; Linda J. Saif; Anastasia N. Vlasova

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)