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This study investigates how glucagon-like peptide-1 (GLP-1) activates the ERK signaling pathway in MIN6 pancreatic beta cells through L-type voltage-gated calcium channels (VGCC). The findings reveal that sustained activation of L-type VGCC is essential for prolonged ERK activation, which occurs independently of global increases in intracellular calcium concentration. The research highlights the significance of localized calcium signaling within the VGCC microdomain in mediating GLP-1
- Author
- 12i282.alevel
- Language
- EN